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Kroemer G, Lopez-Otin C, Madeo F, de Cabo R
Worley ML, Patel KG, Kilpatrick LA
Built from an ultra-pH-sensitive copolymer with a defined transition threshold, this system requires highly acidic lysosomal pH together with cathepsin B activity to trigger release of the TLR7/8 agonist IMDQ
Cytokine levels are expressed as percentage with respect to those measured in control cells (whose IL-10 level is set at 100%)
10.1046/j.1365-2362.2000.00736.x 25 DiasV.JunnE.MouradianM
Unfortunately, toxins worsen the problem by depleting lysine (see Toxins and Lysine Impairment)
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