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There are also certain drugs and health conditions that can increase the likelihood of developing a B12 deficiency such as: alcohol abuse, antacid use, smoking, celiac disease, other digestive concerns, pregnancy, a strict vegetarian or vegan diet, and even natural aging

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Drug Discov Today 26:916930 La Rosa P, Petrillo S, Fiorenza MT, Bertini ES, Piemonte F (2020) Ferroptosis in Friedreichs ataxia: a metal-induced neurodegenerative disease

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Glutathione binds to toxins in the liver, allowing them to be excreted more efficiently

Furthermore, in contrast to Sod3, tissue Gpx3 was predominantly detected in the insoluble protein fractions, as judged from quantitative detergent solubility profiling (QDSP) generated by Schiller et al