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Potential therapeutic role of L-carnitine in skeletal muscle oxidative stress and atrophy conditions

Lancet Gastroenterol Hepatol 2022;7:416-425

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Glutathione is an important antioxidant in the lungs, but its concentration is low in the airways of patients with cystic fibrosis, since GSH is transported into the airways by the cystic fibrosis transmembrane conductance regulator, which is mutated in cystic fibrosis patients (111)

By these manners, NAC can mitigate ROS and inhibit osteoclast differentiation via regulating redox signaling pathways, thereby reducing oxidative stress-mediated bone resorption (Table 3)