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Experts Urge Long-Term Strategies Beyond Medication Based on the findings, the authors conclude: "This evidence cautions against short term use of weight management medications, emphasizes the need for further research into cost effective strategies for long term weight control, and reinforces the importance of primary prevention." A US researcher echoed these concerns in a linked editorial, writing that "The study findings cast doubt on the notion that GLP-1 receptor agonists are a perfect cure for obesity." "People taking GLP-1 receptor agonists should be aware of the high discontinuation rate and the consequences of cessation of medications," he adds

Small peptides derived from exendin 939 inhibit TRPV1 activation and attenuate CAP-induced spontaneous pain in mice To verify the lack of GLP-1R involvement in the observed effects of exendin 939, we roughly fragmented exendin 939 into three small peptides, i.e., exendin 929, 1432, and 2039 (Fig

Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study)

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Accessed September 24, 2025

6, 1981, pp