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This combination is delivered through a pre-filled injection pen system, ensuring ease of use while maintaining accurate dosing and consistency across applications
The neurological aspects of the disease are thought to arise from the accumulation of methylmalonyl- CoA due to the requirement of B 12 as a cofactor to the enzyme methylmalonyl-CoA mutase
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Inclusion criteria selected for patients with a diagnosis of epilepsy, an average of at least 2 seizures per month over the preceding 3 months prior to starting MAD, at least 18 years of age at the time of enrollment, having baseline carnitine lab measurement prior to starting MAD, and at least one carnitine lab measurement at a follow-up timepoint
J.PlewesK.GriggM
Figure 7 3.4 Candidate gene identification and functional annotation To identify candidate genes underlying seed longevity and vigor traits, we examined 2Mb upstream and downstream of the genomic regions associated with these traits
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