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Several mid-stage trials will read out in 2025 to provide important proof points for novel MoAs and their potential for differentiation, e.g., Lillys bimagrumab (activin/myostatin type II receptor inhibitor) in combination with semaglutide, aiming to deliver weight loss while preserving muscle mass (phase 2b)

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Whilst Rybelsus (semaglutide) does not cause dangerous withdrawal symptoms, stopping this type 2 diabetes medication suddenly without medical supervision is not recommended

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