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Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues

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The available maintenance doses include: 5 mg once weekly 7.5 mg once weekly 10 mg once weekly 12.5 mg once weekly 15 mg once weekly (maximum approved dose) Dose escalation decisions should be individualized based on several factors, including weight loss response, tolerability of gastrointestinal side effects, and overall treatment goals

PHQ-9 was already climbing before the escalation finished (12 at week 21), and by week 24, it had reached 17 with HDRS-17 back at 20

As GLP-1 agonists, semaglutide can mimic the effects of GLP-1, such as increasing insulin production, thus decreasing blood glucose levels and slowing gastric emptying, serving as a weight-loss medication