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Intensification to Injectable Therapies (GLP-1 RAs and Basal Insulin): Consensus of the American Diabetes Association and European Association for the Study of Diabetes

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The notion that GLP-1 analogues may affect feeding even when they do not enter the brain is supported by studies showing that large molecular size GLP-1 receptor agonists (albumin-conjugated GLP-1 receptor agonists), that cannot cross the blood-brain barrier can inhibit feeding in both humans and mice

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Systemic adverse effects may include dizziness, drowsiness, confusion, blurred vision, nausea, vomiting, and respiratory depression

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