The thiamine-induced increases in contractions of the intestine smooth muscle and peristalsis, observed in a number of independent in vitro experiments on muscle strips of gastrointestinal tract (207, 219222), support the action of thiamine on ACh signaling in ENS in the absence of central regulation (236)
But theres individual variation
Plus, GLP-1 agonists arent for everyone and can result in undesirable side effects
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However, the elimination of publication bias using trim and fill analysis revealed that NAC also could decrease E2 levels and endometrial thickness