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Surrogate Endpoints for Evaluation Clinical trials for MASH use liver biopsy assessments to evaluate fibrosis staging as a surrogate marker for clinical benefit

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Patients should be advised: Call 999 immediately for chest pain, sudden severe headache, difficulty speaking, facial drooping, arm weakness, or other signs of stroke or heart attack Call NHS 111 for urgent non-emergency advice about new or worsening cardiovascular symptoms, including persistent palpitations or unexplained dizziness Conversely, if blood pressure does not improve as expected with weight loss or worsens this should prompt reassessment of the overall cardiovascular risk profile and consideration of additional investigations

Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management

Chin J Obstet Gynecol Pediatr (Electron Ed)

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