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The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39

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EMA, European Medicines Agency

TMA is a product of the microbial 3,4,5,6 (predominately Firmicutes) metabolism of phosphatidylcholine 7,8 , choline 8 , and L -carnitine 9,10,11 , components of the high-fat, high red meat western diet

Real-world data from electronic health records tells a similar story, though the gap narrows somewhat in patients who also have type 2 diabetes

To control it, inject a small amount of air into the vial first (about 0.5 mL) through the needle before adding water