Plan for a process, not a single procedure : Visible improvements appear over several months, so patience is key
The available evidence indicates quite convincingly that SSRI use may play a causal role in upper gastrointestinal bleeding and that these drugs may act synergistically with other bleeding risk-increasing medications such as NSAIDs or low-dose aspirinPatients should be informed about the likelihood of possible upper gastrointestinal bleeding and high-risk patients should be followed closely. Psychiatric Drugs and ALS A research team at the Karolinska Institute in Sweden announced a worrisome drug complication ( JAMA Network Open , June 4, 2025)
Physiological bloodbrain transport is impaired with age by a shift in transcytosis
In fact, there are no NICE guidelines relating to Pernicious Anaemia, just a Clinical Knowledge Summary which has a glaring error in it (weve pointed this out to NICE who are considering revising it)
The E1 subunits of the 2-oxoadipate dehydrogenase complex are encoded by the DHTKD1 gene while the E2 and E3 subunits are shared with the 2-oxoglutarate dehydrogenase (-ketoglutarate dehydrogenase) complex of the TCA cycle
This means that even if a label promises a high dose, your cells may only receive a tiny fraction of it