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When you produce thyroid hormones (T4 and T3) your body also produces some hydrogen peroxide free radicals

This hyper-proliferative state drains the body's metabolic energy and drives the profound fatigue seen in these conditions

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It is unclear if phellodendron might have this same effect

Metformin directly acts on mitochondria to alter cellular bioenergetics

To our knowledge, this is the first intervention to specifically target microglial lipid-metabolic dysfunction evoked by butyrate depletion, providing pre-clinical proof-of-concept for repurposing butyrate against MPs-triggered neurotoxicity and broadening its therapeutic scope in neurodegenerative diseases