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A Cornerstone for Cardio-Renal-Metabolic Care For patients with diabetes or CKD, GLP-1 therapies deliver benefits that extend well beyond weight loss: Direct Kidney Protection GLP-1 receptor activation can: Lower intraglomerular pressure Promote natriuresis Reduce activity of the renin-angiotensin-aldosterone system Limit renal inflammation, oxidative stress and fibrosis These mechanisms collectively slow CKD progression and help preserve renal function

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While transdermal patch delivery systems are under investigation, all commercially available GLP-1 therapies require subcutaneous injection (semaglutide, liraglutide, dulaglutide, tirzepatide) or oral administration (Rybelsus)

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