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Moreover, adequate safety margins were observed in repeat-dose rat and monkey toxicology studies, which supported advancing PF-06882961 to human clinical studies

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Figure 2 Many studies indicate that several SLC7A11-high cancers are sensitive to glucose deprivation, however the exact mechanism here remains an active area of research

One of the main identified targets is the nitric oxide (NO) pathway, where the peptide acts as a modulator of NO synthesis via NO synthase (NOS) enzymes

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