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In clinical trials, tirzepatide significantly reduced HbA1c levels (by up to 2.24%) and promoted substantial weight loss (by up to 11.2 kg) ( Molecular Mechanisms: Tirzepatide may positively impact cardiovascular health through multiple mechanisms (see Figure 3)

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The mRNA level of asparagine synthetase ( ASNS ), which plays roles in protein synthesis, was significantly decreased in the L-carnitine group in the fasting state, both the liver and muscle (Fig