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A more than twofold increase in nuclear size associated with marked hyperchromatism or prominent nucleoli qualifies as severe atypia
doi: 10.4049/immunohorizons.1800006 115 ZhangH.BernuzziF.LleoA.MaX.InvernizziP
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5 amino 1MQ (NNMTi) is a small molecule compound that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in energy metabolism and fat storage
Leaner individuals may need the shallower 45 degree angle to avoid reaching muscle tissue
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