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In this review, we emphasize on (1) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (2) importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID-19 disease, (3) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (4) new therapies that include antioxidant defenses restoration
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Though the trend did not reach significance, NAC-treatment appeared to maintain or slightly increase maternal GSH levels from enrollment to delivery, whereas the decline in maternal blood GSH expected with duration of pregnancy 43 was observed in the placebo arm
In addition, EA was found to have poor low oral bioavailability, thus limiting its clinical applications
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