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According to one study , glutathione helps reduce oxidative stress by either stimulating or reducing the bodys immunological response

Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome

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Common adverse effects include, but are not limited to, hyperpigmentation, gastrointestinal upset, arthralgia, headache, dizziness, and trouble sleeping

As to the pi class, GSTP1-1 point mutations in both exon 5 (codon 105) and exon 6 (codon 114) were observed and shown to have an impact on the enzymatic activity 32

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