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Horn DB et al ., 2025

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Even brief periods of discontinuations or interruptions might progressively erode and could ultimately reverse this protection, increasing the risk of cardiovascular events, the researchers wrote

2004 Jun;81(6):1578-84

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But the AOD 9604 and tirzepatide stack attacks the problem from two entirely different directions, creating what some clinicians describe as a synergistic metabolic advantage that neither compound achieves alone