Unintentional weight loss : Beyond expected therapeutic weight reduction, or inability to maintain adequate nutrition
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BCS1L mutations are the most common cause of complex III deficiency and are linked to GRACILE syndrome, Bjrstand syndrome, liver disease, encephalopathy, dyskinesia, and epilepsy
In this regard, it is noteworthy that metformin increases intestinal glucose utilisation [3], which perhaps could be coupled to GLP-1 production