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Potential Causes of Allodynia Allodynia is associated with several neurological and metabolic conditions, including: Peripheral Neuropathy (due to diabetes, chemotherapy, or autoimmune disorders) Fibromyalgia (central pain sensitisation disorder) Migraine Disorders (involving trigeminal nerve hypersensitivity) Neuroinflammation and Immune Dysregulation (as seen in post-viral syndromes) Medication Side Effects, including possible links to GLP-1 receptor agonists Mechanisms: How GLP-1 Medications May Contribute to Allodynia GLP-1 receptor agonists (e.g., Mounjaro, Wegovy) are widely used for weight loss and glycemic control due to their role in glucose-dependent insulin secretion and appetite suppression

Sulfonylureas trigger insulin release directly, so pairing them with semaglutide's appetite-suppressing effect creates redundant mechanisms that can send glucose plummeting

#DiabetesManagement #Healthcare #PharmacyStudent #Innovation #NovoNordisk #Awiqli To view or add a comment, sign in Clinical Spotlight: Olanzapine in a Diabetic Patient A Ward Round Case Worth Discussing As pharmacists, we often see olanzapine and diabetes mellitus co-existing on the same chart but how often do we pause to interrogate the interaction, not just the indication

Tan TM, Salem V, Troke RC, Alsafi A, Field BC, De Silva A, et al

Cagrilintide rebuilt the molecule for duration and for obesity rather than glucose alone

Acetyl-L-Carnitine (ALCAR) is another great option, especially if you want additional cognitive support