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New Obesity Drugs: Why Wave-007 Is Stealing the Spotlight Episode Timeline & Main Topics 00:00 Opening & Community Update First week doing the podcast fully live thanks to the On The Pen community Overview of why this weeks news is a major turning point in obesity medicine 02:30 Introducing the One-and-Done Obesity Drug (Wave Life Sciences) WVE-007 early data drops Why this therapy is unlike GLP-1s or any nutrient-stimulated hormone Fat loss results and lean-mass increase 06:30 How Wave-007 Works: INHBE Gene Silencing Mechanism behind visceral fat reduction Why this shifts the field toward quality of weight loss 09:15 Why Lean-Mass Preservation Matters Current GLP-1 medications and muscle loss Why women dominate trial enrollment and the larger implications Medicare patients and the coming wave of GLP-1 coverage 13:45 The Future of Maintenance Therapies Fractyl Health Revita results Lillys orforglipron maintenance design Why holding the line after GLP-1 therapy is the next major category 17:30 Amylin Agonists: Cagrelintide vs

These investigations have demonstrated: Weight reduction: Consistent evidence shows GLP-1 RAs produce greater weight loss than metformin or lifestyle modification alone in women with PCOS and overweight/obesity Improved insulin sensitivity: Markers of insulin resistance, including HOMA-IR scores, show significant improvement Menstrual regularity: Some studies report improved menstrual cyclicity, likely secondary to metabolic improvements Androgen levels: Modest reductions in testosterone levels have been observed in some trials A 2020 systematic review examining GLP-1 agonists in PCOS found promising metabolic benefits but highlighted the limited number of participants and short follow-up periods in existing studies

responsive, available and so incredibly helpful

Tosin reflected that there are still plenty of paths forward

To Issue 160 C itation: Giacon M, Gordon J, Delivering on GLP-1 Demand: a Combination of Device Offerings and Supply Strategy

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