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Melasma: an up-to-date comprehensive review

and Ramasamy, R., 2018

Choose a clinician who will titrate slowly, monitor labs and symptoms, and plan cycles rather than indefinite use

Ademola, J., Ajgaonkar, A., Debnath, T., et al

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In the multicenter PIVENS ( PI oglitazone versus V itamin E versus placebo for the treatment of N onalcoholic S teatohepatitis) trial, 247 subjects with MASH but not diabetes mellitus were randomized to receive 30 mg/day of pioglitazone (an insulin-sensitizing drug), 800 IU/day (536 mg/day) of RRR --tocopherol, or a placebo for 96 weeks (97)