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Originally, Tesamorelin was FDA-approved for HIV-related fat redistribution

[200] [202] [198] Because conventional PKC isoforms can be activated by Ca 2+ and diacylglycerol, elevated intracellular calcium can promote PKC-dependent DAT phosphorylation independent of TAAR1

There were no differences in the glycaemic indices of insulin and HOMA-IR between the treatment and placebo groups (Table II)

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Molecular and cellular endocrinology, 464, 6574