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Serious adverse events pancreatitis, gallbladder disease, hypoglycemia in patients on concurrent insulin secretagogues are class effects of GLP-1 receptor agonists and apply equally across all three forms

Data released in March 2025 showed that GLP-1 medications were contributing about 15% of monthly revenue at medspa practices offering them, American Spa reported

For you to qualify for the Medicare GLP-1 Bridge, a provider must submit a prior authorization request that attests the beneficiary meets the following criteria: The beneficiary is prescribed the requested drug to reduce excess body weight and maintain weight reduction in combination with current and ongoing lifestyle modification including structured nutrition and physical activity consistent with the applicable FDA approved label, AND The beneficiary is at least eighteen (18) years of age and has a BMI greater than or equal to thirty-five (35) at the time of initiation of GLP-1 therapy, or The beneficiary is at least eighteen (18) years of age and has a BMI greater than or equal to thirty (30) at the time of initiating GLP-1 therapy with a diagnosis of one or more of the following: (A) heart failure with preserved ejection fraction, (B) uncontrolled hypertension (defined as systolic blood pressure above 140 mm Hg or diastolic blood pressure above 90 mm Hg, despite concurrent treatment with two antihypertensive medications), or (C) chronic kidney disease stage 3a or above, or The beneficiary is at least eighteen (18) years of age and has a BMI greater than or equal to twenty-seven (27) at the time of initiating GLP-1 therapy with a diagnosis of one or more of the following: (A) pre-diabetes (as defined by American Diabetes Association guidelines), (B) previous myocardial infarction, (C) previous stroke, or (D) symptomatic peripheral artery disease

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Currently, their use in Parkinson's remains experimental, with no NHS or NICE recommendation outside of clinical trials

With all these lines of inquiry, I think it will be important to determine how much of the benefit comes directly from GLP-1R therapy itself, and how much is actually secondary to the weight loss it causes