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Persistent or severe nausea and vomiting Ongoing gastrointestinal issues after treatment may suggest that your body is not processing the infusion properly

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If you take Vyvanse early enough, it shouldnt keep you awake, but if it does, mention it to your doctor (sometimes shifting to an earlier time helps)

For patients experiencing intense or persistent gastrointestinal effects, temporarily maintaining the current dose or extending the escalation phase by 2-4 weeks often proves effective

Work Cited (n.d.)