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Tuchman M, Caldovic L, Daikhin Y, et al
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Superimposing the TMD of GLP-2R with that of GLP-1R reveals that activated GLP-2R shows a similar conformation to that of GLP-1-bound or ExP5-bound GLP-1RG s complexes 13,17 (C RMSD = 1.41 and 0.91 , respectively), distinct from inactive GLP-1R 33 (C RMSD = 1.79 )
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For now, and in the context of GLP therapy, it will be important to first better understand the insulin release and response kinetics in normal weight, nondiabetic patients before recommending these meds for a broader population.
Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice
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