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Mechanistically, lactate contributes to the intracellular acetyl-CoA pool through its conversion to pyruvate, followed by subsequent metabolism (74)
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In the context of statin research, their antitumor effects can be attributed to the disruption of protein prenylation, reduction of cholesterol levels, modulation of autophagy, promotion of ferroptosis in tumor cells, and inhibition of their proliferation and invasion[178]
Science 366 , 10131021 (2019)
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