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However, it needs to be said that these studies were conducted on animals

Hepatology 41 , 13131321 (2005)

For deficiency without neurological involvement or for borderline levels, oral supplementation with high-dose cyanocobalamin (1000-2000 mcg daily) is often effective, as approximately 1% of an oral dose is absorbed through passive diffusion even in the absence of intrinsic factor

Additionally, many patients give up the treatment, whether because they are buying it privately so cannot afford it, because the side-effects do not suit them or because they are not losing weight any more

King has seen much success with this treatment but Salkey notes that the earlier you start it, the better your results will likely be

Gould, Premature skin ageing signs due to androgen deprivation therapy