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ASPN is an extracellularly secreted protein that is reported to be predominantly expressed in stromal CAFs in malignant pathogenesis of human pancreatic [33], colorectal [34] and gastric cancers [35]

For example, severe neuroinflammation (brain fog) can dysregulate the autonomic nervous system, leading to worsened POTS symptoms (tachycardia), which in turn triggers mast cell degranulation (histamine release)

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ROS are highly reactive, unstable molecules our bodies produce during normal metabolism and in response to environmental stresses

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