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Approved Versus Investigational Benefits The FDA-approved benefit is reduction of excess abdominal fat in adults with HIV-associated lipodystrophy

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These optimize the levels of neuroendocrine hormones in the gut

In refractory autoimmune conditions such as refractory systemic lupus erythematosus (with or without subsequent stem cell transplant), rheumatoid arthritis, multiple sclerosis or hemolytic anemia etc., high-dose CTX (200 mg/kg) is a part of several treatment protocols (101106)

Studies show FOXO4-DRI treatment reduces senescent cell burden by 50-70% in various tissues including liver, kidney, and adipose tissue within weeks of treatment initiation in aged mice

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