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GLP-1 is both influenced by and exerts effects on variables like the microbiome, eating behaviour, glucose tolerance, metabolic profile, medication, sex and weight

Its a small trial with only 1-year follow up and lacking hard endpoints such as hospitalization or cardiovascular deaths, but the results for symptomatic relief and gain in physical activity are certainly very encouraging

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Patients with variants linked to lower GLP-1 receptor expression may benefit from consistent, predictable dosing schedules that allow the medication to accumulate over weeks, while those with high-sensitivity variants often feel effects more rapidly after each injection

And we use it for weight loss, too