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In trained monocytes, elevated NAD + /NADH ratios and lactate accumulation modulate HDAC activity and influence downstream gene expression (167, 168)
The upregulation of interferon-stimulated gene 15 in TECs disrupted mitochondrial homeostasis and triggered the release of mtDNA into the cytosol, which then triggers NLRP3mediated pyroptosis in cyclic GMP-AMP synthase-stimulator of interferon genes pathway (47)
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For psoriasis, topical peptides can deliver high concentrations directly to inflamed plaques without significant systemic exposure
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