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Observations in rodent studies suggest that increases in bone mineral content may reflect structural adaptations, rather than changes in volumetric bone density

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Additionally, the same cohort was exposed after the supplementation periods (NAC and placebo) to 6 hours of normobaric hypoxia (16.1% O2, simulating 2500m / 8000ft), with serial measures of serum EPO and arterial oxyhemoglobin saturation (via pulse oximetry)

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This, in turn, limits the availability of SAMe for methylation 12