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Indeed, several studies have demonstrated that aberrant IGF signaling plays a critical role in the pathogenesis and progression of several types of cancer, including lung, breast, colon, prostate, ovary, pancreas, and thyroid ( Nevertheless, data coming from observational studies are still conflicting and inconclusive, since some authors observe an association between insulin therapy and increased cancer risk (Tseng, 2019

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Cochrane Database Syst Rev 1183 Wong CR, Nguyen MH, Lim JK (2016) Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

Advances in Bioscience and Biotechnology, 15 , 573-589