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Doctors prescribe it at a higher dose to achieve significant weight loss

By acting on GLP-1R, GLP-1 also delays gastric emptying and enhances satiety by inhibiting postprandial gastrointestinal motility and gastric acid secretion, making GLP-1 analogues promising anti-obesity agents (33,46)

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While a few non-electrophilic, non-covalent TRPA1 activators are reported (e.g., carvacrol) 4 , only one (PF-4840154) is especially potent 22

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Because of this, it's generally considered safe for most people