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Whats driving this and will it continue
The convergence of enabling technologies, conceptual shifts toward polypharmacology, improved mechanistic tools, and evolving regulatory frameworks has fundamentally altered the translational calculus
Nonetheless, it is unclear whether the protective effect of GLP-1R agonists on fat content stems from weight loss, which, among other things, increases insulin sensitivity and improves glycemia and lipid profile, or from direct activation of the hepatic GLP-1R
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& Mansel, R
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