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They should also be made aware of the increased risk of heart disease and retinopathy that may be associated with the drug
Currently in the UK, only the semaglutide brand Ozempic is available to people with a BMI of over 30
[4] It is important to distinguish pancreatitis from the common gastrointestinal side effects that affect many semaglutide users, particularly during dose escalation
lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks
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Plotting reduction in BMI shows that while there were reductions with semaglutide, there were relatively greater, dose-dependent reductions seen with tirzepatide, and again we see greater reductions in waist circumference, seeing around a 10 cm reduction in waist circumference with tirzepatide 15 mg once weekly
