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Dosing adjustments are based on real clinical signals rather than rigid schedules

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Data were analysed using one-way ANOVA with Bonferroni post hoc multiple-comparison test ( b , d , h , k , m , o , p ), two-way repeated-measures ANOVA ( a , c , e g , j , l ) or Kruskall-Wallis test with uncorrected Dunnss test ( i , n )

The pattern in trials has been broadly consistent with other incretin-based therapies (such as Mounjaro and Wegovy), and most side effects have been mild to moderate and dose-dependent, occurring mainly during the initial dose-escalation period