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In a mouse study from the University of Utah , animals treated with semaglutide lost about 10% of lean mass overall with skeletal muscle itself decreasing by about 6% , and muscle strength declining disproportionately to size ( University of Utah Health )

This recommendation is based on compelling evidence: an early-responder analysis showed that 93.4% of patients who failed to meet the 16-week threshold were also unable to achieve a substantial (10%) weight reduction after a full year of treatment

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Angeli, J