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Under the same experimental format as Figure 1e left column, except using a molar ratio of GSSSG and LASSS to HGF (1:8000), LASSS-treated HGF (Figure 1e right column, bar 9 ) displayed about 2-fold higher c-met binding than the control HGF level ( bar 8 , in which HGF just received the solvent) equivalent to the positive controls ( bars 2 and 2 in the left column)
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this observation suggests that inactivation of the GPx3 gene by hypermethylation of the promoter may contribute to breast cancer progression
Graphs presenting time courses of F340/F380 ratio changes have been obtained by averaging data from a population of cells recorded individually during one single representative experiment
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The CDKN2A (p16) gene and human cancer
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