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This worsens insulin resistance and increases risk of diabetes, cardiovascular disease, liver disease, and even some cancers (See The Dangers of Excess Insulin) (Wolpin 2013

When Symptoms Worsen: Understanding the Adjustment Period The period following B12 injection therapy can be challenging for some patients, with symptoms sometimes temporarily intensifying before improvement becomes apparent

These studies underscore the comparative effectiveness of Mounjaro, particularly in how it may offer a more pronounced weight-loss effect over a similar time frame compared to alternatives

If you are also taking insulin or sulfonylureas (such as gliclazide), your doctor may need to reduce these doses when starting Ozempic to reduce the risk of hypoglycaemia (low blood sugar)