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As the body adjusts to the dosage, they fade

Nrf2 displays both pro- and anti-atherogenic effects in experimental animal models, and the Nrf2 pathway becomes a promising target for atherosclerosis prevention (234)

It can also cause side effects, like nausea and bloating at first, so its important to start slow

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However, physical exercise also results in the generation of reactive oxygen species (ROS) in exercising muscle, which is why it is important to replenish your body with antioxidants such as glutathione