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Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Victoza Important Safety Information for Victoza WARNING: RISK OF THYROID C-CELL TUMORS Liraglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures in both genders of rats and mice
Nat Rev Endocrinol 14 , 390403 (2018)
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Acknowledgements This study was funded by National Natural Science Foundation of China General Program (Grant number: 82070375, to K.L.)
Additionally, GLP-1R signaling in -cells activates mTOR-dependent transcription of hypoxia-inducible factor 1 alpha (HIF-1), which upregulates glucose expression and promotes glucose metabolism [8, 9]
doi:10.1177/0300060516663094
