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Copper is an essential trace element crucial for many enzymatic reactions and plays a key role in collagen and elastin synthesis, as well as antioxidant defense

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This means that instead of these macronutrients going unused, B12 helps them fuel your body for extra energy

[51] Diagnosis [edit] According to one review: "At present, no 'gold standard' test exists for the diagnosis of vitamin B 12 deficiency and as a consequence the diagnosis requires consideration of both the clinical state of the patient and the results of investigations." [52] The vitamin deficiency is typically suspected when a routine complete blood count shows anemia with an elevated mean corpuscular volume (MCV)

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