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Key points Amyotrophic lateral sclerosis (ALS), with a lifetime risk of ~1/350, represents an area of huge unmet need and is a useful model of neurodegeneration, with measurable changes in motor function over a relatively short time frame

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Cagrilintide alone trails semaglutide and tirzepatide in weight-loss magnitude

Storage Store in a cold, dry place away from heat sources

Every dose and outcome figure comes from the Novo Nordisk trial programme (REDEFINE 1 and 2, the phase 2 dose-finding trial and the phase 1b combination study) or from their registry records

IV Therapy can be administered safely during pregnancy