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The most common adverse effects associated with GLP-1 medications are gastrointestinal in nature, including nausea, vomiting, diarrhea, constipation, and abdominal discomfort
In a study on rats, DSIP demonstrated an analgesic effect, increasing the threshold for pain response (Gyermek et al., 1981)
doi: 10.1007/s13668-018-0248-8 8
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