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Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

Samples were resolubilised in MeOH and analysed using a reversed phase HPLC as described in [37] and LC-MS (Agilent 6340 ETD LC-MS system)

The goal is to let the hypothalamic-pituitary axis adjust gradually

In this regard, increased loss of glutathione may change the intracellular environment to a prooxidant state and thereby caused prominent changes in gene expression, which is ultimately evolving into a malignant state [26]

Be consistent Most protocols suggest once or twice daily use