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By offering a more sustained release profile, this GLP-1 patch could significantly reduce the gastrointestinal side effects associated with GLP-1 therapy, a key factor in high treatment discontinuation rates
Exendin-4 was also shown to have beneficial effects on fibroblast function, metabolic, inflammatory, and healing markers in diabetic rat models
Instead, lean mass had increased by 2.7%, which could explain there being no change in apparent body weight ( Supplementary Figure 1 )
Why it matters: Cigna joins a growing list of employers and insurers scaling back GLP-1 weight loss drug coverage as prescriptions surge
Understanding where the science is heading helps set realistic expectations about what we know now versus what we might learn soon
The distinct result may be due to differences in molecular structure that affects the potency, duration, and frequency of use ( The strength of this study lies in the very large number of patients used, the largest to-date, that focused on anxiety or depression associated with using GLP1-RA for the treatment for DM
